Highlights • A network-based approach, creating a network comprising 29 SARS-CoV-2 proteins interacting with 2896 human host proteins. • Network find 176 host genes interacting with all viral proteins and involved in translation, splicing and ribosomal pathways. • Top 5 most connected hub genes in the disease-associated network were determined to be EEF2, RPS3, RPL9, RPS16, and RPL11. • 292 drug molecules were discovered to interact with hub genes and 13 molecules were found to interact with all hub genes. • Estradiol was identified as interacting with all the hub genes in the drug-gene interaction databases.
All Keywords
【저자키워드】 COVID-19, Drug repurposing, Comorbidity, SARS-CoV-2 proteins, Host interacting genes, Ribosomal pathways,
【저자키워드】 COVID-19, Drug repurposing, Comorbidity, SARS-CoV-2 proteins, Host interacting genes, Ribosomal pathways,