Immediate postpartum cessation of tenofovir did not increase risk of virological or clinical relapse in highly viremic pregnant mothers with chronic hepatitis B infection

Highlights • The optimal time to stop peripartum antiviral prophylaxis with tenofovir after delivery is unknown. • Stopping tenofovir immediately at delivery did not increase risk of virological relapse, clinical relapse, or retreatment. • Transmission of HBV from the mother to the baby was observed in 0% of infants. • Shortening the duration of tenofovir peripartum prophylaxis from 12 weeks to immediately after delivery can be considered.