Ceria nanoparticles (CeO 2} NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO 2} NPs. Due to the wide application of CeO 2} NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO 2} NPs, including their use in the treatment of various diseases (e.g., Alzheimer’s disease, ischemic stroke, retinal damage, chronic inflammation, and cancer). CeO 2} NP toxicity is discussed in terms of the different systems of the human body (e.g., cytotoxicity, genotoxicity, respiratory toxicity, neurotoxicity, and hepatotoxicity). This comprehensive review covers both fundamental discoveries and exploratory progress in CeO 2} NP research that may lead to practical developments in the future.
【저자키워드】 Toxicity, oxidative stress, biomedical application, Ceria nanoparticle, Synthetic method, 二氧化铈纳米颗粒, 合成方法, 毒性, 氧化应激, 生物医学应用程序,