Highlights • The Alpha mutation has caused the S976-Alpha peptide to flip ‘upside down’ when bound by HLA-A*02:01. • Despite weaker binding affinity to S975 predicted for HLA-A*02:01, a modest T cell activation and cross-reactivity was observed. • HLA-A*11:01 presents S975 and its variants in similar conformation but not the HLA-B*13:01. • Limited S975-specific T cell cross-reactivity was observed in HLA-A*11:01+ samples.
All Keywords
【저자키워드】 SARS-CoV-2, T cells, X-ray crystallography, HLA, viral mutation, Viral epitopes,
【저자키워드】 SARS-CoV-2, T cells, X-ray crystallography, HLA, viral mutation, Viral epitopes,