The mechanisms driving B cell differentiation into resident bone marrow plasma cells (BMPC) remain unclear. Here the authors use single cell sequencing and BMPC phenotyping to infer developmental pathways and regulation by IL-21 in germinal centres to promote maintenance of BMPC after vaccination in humans.
All Keywords
【저자키워드】 antibodies, RNA vaccines, Immunological memory, Gene regulation in immune cells, Plasma cells,
【저자키워드】 antibodies, RNA vaccines, Immunological memory, Gene regulation in immune cells, Plasma cells,