Bartfeld and colleagues examined the susceptibility of gastrointestinal organoid-derived monolayers to SARS-CoV-2 infection. They observed productive infection in intestinal, but not gastric, cells. Susceptibility correlated with ACE2 expression in organoids and patient tissues. Ectopic ACE2 expression rendered gastric organoid-derived monolayers susceptible to SARS-CoV-2, leading to the conclusion that ACE2 expression in gastrointestinal epithelium is the key limiting factor for SARS-CoV-2 infection.
All Keywords
【저자키워드】 SARS-CoV-2, ACE2, intestine, organoids, infection model, stomach, gastrointestinal epithelium,
【저자키워드】 SARS-CoV-2, ACE2, intestine, organoids, infection model, stomach, gastrointestinal epithelium,