Background As pregnancy is a physiological prothrombotic state, pregnant women may be at increased risk of developing coagulopathic and/or thromboembolic complications associated with COVID-19. Methods Two biomedical databases were searched between September 2019 and June 2020 for case reports and series of pregnant women with a diagnosis of COVID-19 based either on a positive swab or high clinical suspicion where no swab had been performed. Additional registry cases known to the authors were included. Steps were taken to minimise duplicate patients. Information on coagulopathy based on abnormal coagulation test results or clinical evidence of disseminated intravascular coagulation (DIC), and on arterial or venous thrombosis, were extracted using a standard form. If available, detailed laboratory results and information on maternal outcomes were analysed. Results One thousand sixty-three women met the inclusion criteria, of which three (0.28, 95% CI 0.0 to 0.6) had arterial and/or venous thrombosis, seven (0.66, 95% CI 0.17 to 1.1) had DIC, and a further three (0.28, 95% CI 0.0 to 0.6) had coagulopathy without meeting the definition of DIC. Five hundred and thirty-seven women (56%) had been reported as having given birth and 426 (40%) as having an ongoing pregnancy. There were 17 (1.6, 95% CI 0.85 to 2.3) maternal deaths in which DIC was reported as a factor in two. Conclusions Our data suggests that coagulopathy and thromboembolism are both increased in pregnancies affected by COVID-19. Detection of the former may be useful in the identification of women at risk of deterioration. Supplementary Information The online version contains supplementary material available at 10.1186/s12884-021-03568-0.
【저자키워드】 COVID-19, SARS-CoV-2, Coagulopathy, Pregnancy, Birth, Venous thrombosis, Arterial thrombosis, Disseminated intravascular coagulopathy, Haematological complications, 【초록키워드】 thrombosis, risk, detection, outcome, database, Case report, Coagulation, Coagulopathy, pregnant women, Deterioration, Pregnancy, Laboratory results, Thromboembolism, Birth, Venous thrombosis, death, Swab, women, case reports, information, patients, Disseminated intravascular coagulation, physiological, evidence of, maternal deaths, coagulation test, Definition, thromboembolic, Factor, supplementary material, 95% CI, increased risk, abnormal coagulation, clinical suspicion, inclusion criteria, clinical evidence, thromboembolic complications, prothrombotic state, pregnancies, intravascular coagulation, positive swab, arterial or venous thrombosis, step, Seven, Result, performed, affected, reported, analysed, searched, diagnosis of COVID-19, laboratory result, thromboembolic complication, with COVID-19, 【제목키워드】 systematic review, Complication, Critical, Analysis,