Executive summary Green & conventional synthesis of metal nanoparticles Nanomedicine has solved many drawbacks in therapeutics and diagnositics. Chemical and physical metal nanoparticles (MNPs) synthesizes are energy consuming and sometimes associated with accumulation of toxic byproducts. Green biological MNPs synthesis offers an energy saving and cost effective alternative synthesizing procedures. Green biological MNPs synthesis utilizes plants, bacteria, fungi, viruses and algae as MNPs nanofactories. Green biological metal nanoparticles in biological applications Green biological MNPs acquire anticancer and antimicrobial activities due to reactive oxygen species (ROS) generation. Green biological MNPs attain desirable morphologies that enhance their biological activities. AuNPs, AgNPs, ZnO-NPs, CuO-NPs, TiO 2}-NPs and IONPs derived from different biological sources acquire significant antimicrobial, anticancer and antioxidant properties. Biogenic SeNPs are promising therapeutic agents when used alone or incombination with irradiation sources. Biogenic PtNPs retrieved from fungal biomasses acquire promising physiochemical properties for various therapeutic applications. Factors affecting green biological metal nanoparticles synthesis Physical factors such as time, pH, temperature, concentration of precursor solution and biological biomasses affect the yield and physiochemical properties of biogenic MNPs. Optimization of synthesizing technique is essential prior to scaling up production of biogenic MNPs. Future prespectives in green metal nanoparticles synthesis & applications Actinomycetes are potiential MNPs nanofactories that need to be investigated. Statistical optimization techniques and genetic studies may improve optimization techniques and the scaling up of green MNP synthesis. ADPT, hyperthermia and radiotherapies can be combined with green biogenic MNPs. Toxological studies for Green MNPs should be properly investigated.
【저자키워드】 plants, Antibacterial, anticancer, microbes, green synthesis, metal nanoparticles (MNPs),