Francisella novicida Cas9 (FnCas9) has low cellular editing ability which limits its therapeutic utilities. Here, the authors rationally engineer the protein to develop enhanced FnCas9 (enFnCas9) variants with high on-target editing efficiency, high precision, broadened target range, and flexible base editing outcomes.
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【저자키워드】 Molecular medicine, CRISPR-Cas9 genome editing, genetic engineering,
【저자키워드】 Molecular medicine, CRISPR-Cas9 genome editing, genetic engineering,