Highlights • AhRR deficiency ameliorates diet-induced obesity in mice. • AhRR expression in macrophages reduces mitochondrial activity and ROS production. • Myeloid cell-specific AhR- but not AhRR deficiency increases liver damage. • Adipose tissue fibrosis is promoted by inhibition of AhR activation in macrophages.
All Keywords
【저자키워드】 hepatic steatosis, Energy expenditure, metabolic dysfunction, Collagen deposition, Indole-3-carbinol, Macrophage metabolism,
【저자키워드】 hepatic steatosis, Energy expenditure, metabolic dysfunction, Collagen deposition, Indole-3-carbinol, Macrophage metabolism,