Although single-cell RNA sequencing analysis now allows simultaneous examination of transcriptome and T cell receptor repertoire sequences, integrating these two modalities remains a challenge. Here, the authors develop mvTCR, a generative deep learning model that integrates transcriptome and T cell receptor data into a joint representation capturing cell functions and phenotypes.
All Keywords
【저자키워드】 Adaptive immunity, machine learning, Data integration,
【저자키워드】 Adaptive immunity, machine learning, Data integration,