Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping

Published on
Journal: Communications Biology
[저자] Niklas Berndt Thalén, Maximilian Karlander, Magnus Lundqvist, Helena Persson, Camilla Hofström, S. Pauliina Turunen, Magdalena Godzwon, Anna-Luisa Volk, Magdalena Malm, Mats Ohlin, Johan Rockberg
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s42003-024-06508-8    
[Article Type] Article
[Source] PMC

Using a new method for rapid, residue-level epitope determination combining flow cytometry and surface displayed alanine substitution variants the authors determined the epitopes of three new antibodies binding the SARS-CoV-2 Spike protein.

All Keywords
【저자키워드】 Molecular biology, Computational biology and bioinformatics, Target validation,