This study reveals the dose‐dependent disease outcomes of SARS‐CoV‐2 Omicron BA.5 exposure in senescent hamster. High‐dose BA.5 exposure results in impaired IFN I signaling, cytokine storm, uncontrolled viral replication, severe lung injury, and death. Early intervention of bio‐mimic decoy CoVR‐MV rescues critical COVID‐19 by viral load inhibition and simultaneous reserving the imbalanced innate immune response from inflammatory to antiviral.
All Keywords
【저자키워드】 antiviral therapy, SARS‐CoV‐2, immunoregulation, bio‐mimic decoy, senesce associated disease deterioration,
【저자키워드】 antiviral therapy, SARS‐CoV‐2, immunoregulation, bio‐mimic decoy, senesce associated disease deterioration,