Human coronaviruses (HCoVs) that cause seasonal colds achieve long-term adaptation in the human population through a high “glycan shield”. The recent emergence of the SARS-CoV-2 BA.2.86 lineage, with additional N354 glycosylation on the S protein, is an important event in the evolution of SARS-CoV-2 into a human seasonal coronavirus. N354 glycosylation makes the virus more susceptible to the upper respiratory tract, but weakens its ability to replicate in the lower respiratory tract, while reducing the immunogenicity of the virus, which is conducive to future reinfection by the virus. These results suggest that the event of increased glycosylation promotes the coexistence of SARS-CoV-2 with humans.
All Keywords
【저자키워드】 viral evolution, viral fitness, adjustable infectivity, co-factor usage, conformational modulator, coronavirus glycosylation,
【저자키워드】 viral evolution, viral fitness, adjustable infectivity, co-factor usage, conformational modulator, coronavirus glycosylation,