In this study, we traced the trajectory and fate of dysfunctional HBV-specific CD8^{+} T cells and analyzed the modulation of co-signaling receptors following hepatocellular priming. We identified 4-1BB agonism as the most promising strategy to convert these cells into antiviral effectors for treating chronic HBV infections.
All Keywords
【저자키워드】 Immunotherapy, CD8+ T cells, liver, Hepatitis B virus, OX40, T cell dysfunction, Chronic viral infection, 4-1BB,
【저자키워드】 Immunotherapy, CD8+ T cells, liver, Hepatitis B virus, OX40, T cell dysfunction, Chronic viral infection, 4-1BB,