Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.
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【저자키워드】 Molecular medicine, drug delivery, Nucleic-acid therapeutics,
【저자키워드】 Molecular medicine, drug delivery, Nucleic-acid therapeutics,