The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2) in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 (COVID-19). Since then, COVID-19 has been under intense scrutiny as its outbreak led to significant changes in healthcare, social activities, and economic settings worldwide. Although angiotensin-converting enzyme-2 (ACE-2) receptor is shown to be the primary port of SARS-CoV-2 entry in cells, the mechanisms behind the establishment and pathologies of COVID-19 are poorly understood. As recent studies have shown that host mitochondria play an essential role in virus-mediated innate immune response, pathologies, and infection, in this review, we will discuss in detail the entry and progression of SARS-CoV-2 and how mitochondria could play roles in COVID-19 disease. We will also review the potential interactions between SARS-CoV-2 and mitochondria and discuss possible treatments, including whether mitochondria as a potential therapeutic target in COVID-19. Understanding SARS-CoV-2 and mitochondrial interactions mediated virus establishment, inflammation, and other consequences may provide a unique mechanism and conceptual advancement in finding a novel treatment for COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, Mitochondria, Cytokine storm, ACE-2 receptor, 【초록키워드】 pathology, pandemic, innate immune response, Infection, progression, virus, COVID-19 disease, ACE-2, Spread, cells, outbreak, healthcare, understanding, receptor, coronavirus disease 19, angiotensin-converting enzyme-2, Pathologies, mechanism, Interaction, mitochondrial, SARS-CoV-2 entry, activities, potential therapeutic target, scrutiny, Host, consequence, shown, significant changes in, caused, unique, treatment for COVID-19, 【제목키워드】 therapeutic, Host, role,