Highlights • In mice, durable expression and subsequent effects of MSA-IL-22 were observed. • MSA-IL-22 ameliorated metabolic syndrome–associated parameters. • MSA-IL-22 improved body weight in mice with diet-induced MASLD. • Correction of hepatic steatosis and dyslipidemia was also observed. • Data support mRNA-encoded IL-22 as a treatment for metabolic syndrome.
All Keywords
【저자키워드】 Metabolic disorders, Messenger RNA, interleukin-22, metabolic dysfunction-associated steatotic liver disease, Lipid nanoparticle therapeutic, Serum lipid parameters,
【저자키워드】 Metabolic disorders, Messenger RNA, interleukin-22, metabolic dysfunction-associated steatotic liver disease, Lipid nanoparticle therapeutic, Serum lipid parameters,