Here, the authors provide evidence that SARS-CoV-2 N protein leads to autophagic degradation of Dicer, XPO5, SRSF3, and hnRNPA3, inducing DNA damage and proteotoxic stress, eventually causing pneumonia. The small-molecule drug PJ34 or anastrozole alleviates N protein-induced pneumonia.
All Keywords
【저자키워드】 SARS-CoV-2, Protein aggregation, RNA splicing, RNAi, DNA damage and repair,
【저자키워드】 SARS-CoV-2, Protein aggregation, RNA splicing, RNAi, DNA damage and repair,