Background Clinical investigations have argued for long-term neurological manifestations in both hospitalised and non-hospitalised COVID-19 patients. It is unclear whether long-term neurological symptoms and features depend on COVID-19 severity. Methods From a sample of 208 consecutive non-neurological patients hospitalised for COVID-19 disease, 165 survivors were re-assessed at 6 months according to a structured standardised clinical protocol. Prevalence and predictors of long-term neurological manifestations were evaluated using multivariate logistic regression analyses. Results At 6-month follow-up after hospitalisation due to COVID-19 disease, patients displayed a wide array of symptoms; fatigue (34%), memory/attention (31%) and sleep disorders (30%) were the most frequent. At neurological examination, 40% of patients exhibited neurological abnormalities, such as hyposmia (18.0%), cognitive deficits (17.5%), postural tremor (13.8%) and subtle motor/sensory deficits (7.6%). Older age, premorbid comorbidities and severity of COVID-19 were independent predictors of neurological manifestations in logistic regression analyses. Conclusions Premorbid vulnerability and severity of SARS-CoV-2 infection impact on prevalence and severity of long-term neurological manifestations. Supplementary Information The online version contains supplementary material available at 10.1007/s10072-021-05586-4.
【저자키워드】 COVID-19, Depression, fatigue, Cognitive impairment, Hyposmia, 【초록키워드】 protocol, SARS-COV-2 infection, severity, COVID-19 severity, Comorbidity, COVID-19 disease, Prevalence, severity of COVID-19, clinical, Patient, Logistic regression, neurological manifestations, age, Follow-up, predictor, hospitalisation, COVID-19 patients, neurological, sleep disorder, cognitive, supplementary material, multivariate logistic regression, survivor, neurological abnormalities, neurological manifestation, hospitalised, feature, Neurological symptom, Result, evaluated, exhibited, analyses, independent predictor, non-hospitalised, premorbid, 【제목키워드】 Prevalence, Predictive, Factor, neurological manifestation,