Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced an ongoing global health crisis. Here we utilized a combination of targeted amino acids (AAs) and clinical biochemical profiling to analyze the plasma of coronavirus disease 2019 (COVID-19) subjects at the hospitalization stage and 1-month post-infection convalescent stage, respectively, to investigate the systematic injury during COVID-19 disease progress. We found the virus-induced inflammatory status and reduced liver synthesis capacity in hospitalized patients, which manifested with increased branched-chain AAs (BCAAs), aromatic AAs (AAAs), one-carbon related metabolites, and decreased methionine. Most of these disturbances during infection recover except for the increased levels of medium-chain acylcarnitines (ACs) in the convalescent subjects, implying the existence of incomplete fatty acids oxidation during recovery periods. Our results suggested that the imbalance of the AA profiling in COVID-19 patients. The majority of disturbed AAs recovered in 1 month. The incomplete fatty acid oxidation products suggested it might take longer time for convalescent patients to get complete recovery.
【저자키워드】 COVID-19, SARS-CoV-2, amino acids, convalescent stage, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, Hospitalization, Infection, hospitalized patients, severe acute respiratory syndrome Coronavirus, Health crisis, COVID-19 disease, Convalescent patients, Health, amino acids, plasma, metabolites, respiratory, convalescent, liver, Fatty acid, COVID-19 patients, convalescent patient, Amino acid, Combination, Injury, except for, fatty acids, methionine, complete recovery, Post-infection, acute respiratory syndrome, biochemical, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, subject, MOST, AAAs, fatty acid oxidation, inflammatory status, reduced, majority, subjects, suggested, manifested, 【제목키워드】 Hospitalized, Patient, Amino acid,