Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens

Published on
Journal: Nature Communications
[저자] Xandra Nuqui, Lorenzo Casalino, Ling Zhou, Mohamed Shehata, Albert Wang, Alexandra L. Tse, Anupam A. Ojha, Fiona L. Kearns, Mia A. Rosenfeld, Emily Happy Miller, Cory M. Acreman, Surl-Hee Ahn, Kartik Chandran, Jason S. McLellan, Rommie E. Amaro
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s41467-024-50976-9    
[Article Type] Article
[Source] PMC

The evolutionarily conserved SARS-CoV-2 spike’s S2 subunit provides the foundation for its usage as an immunogen in vaccines. Here, the authors use a simulation-driven approach to design S2-only immunogens stabilized in the closed prefusion conformation.

All Keywords
【저자키워드】 Vaccines, molecular dynamics, Protein design, Cryoelectron microscopy, Computational biophysics,