Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes

Published on
Journal: Nature Communications
[저자] Asolina Braun, Louise C. Rowntree, Ziyi Huang, Kirti Pandey, Nikolas Thuesen, Chen Li, Jan Petersen, Dene R. Littler, Shabana Raji, Thi H. O. Nguyen, Emma Jappe Lange, Gry Persson, Michael Schantz Klausen, Jens Kringelum, Shanzou Chung, Nathan P. Croft, Pouya Faridi, Rochelle Ayala, Jamie Rossjohn, Patricia T. Illing, Katherine E. Scull, Sri Ramarathinam, Nicole A. Mifsud, Katherine Kedzierska, Anders Bundgård Sørensen, Anthony W. Purcell
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s41467-024-51959-6    
[Article Type] Article
[Source] PMC

The immune response to the spike protein of SARS-CoV-2 has been relatively well studied, but less is known about other viral proteins. Here, the authors identify immunopeptides from seven structural and non-structural SARS-CoV-2 proteins presented to the immune system by HLA molecules and confirm T-cell responses against some of them in convalescent individuals.

All Keywords
【저자키워드】 SARS-CoV-2, proteomics, Peptide vaccines, cellular immunity,