The SARS-CoV-2 protein Nsp1 is a major virulence factor due to its role in host translation shutoff and viral evasion. Wang et al. present the atomic-resolution structure of full-length Nsp1, revealing hitherto unknown features that provide the basis for unraveling its functional regulation and guiding future drug-design strategies.
All Keywords
【저자키워드】 SARS-CoV-2, drug targets, non-structural proteins, NMR spectroscopy, nsp1, disordered protein domains,
【저자키워드】 SARS-CoV-2, drug targets, non-structural proteins, NMR spectroscopy, nsp1, disordered protein domains,