Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

Published on
Journal: Cell Reports
[저자] Saskia Meyer, Isaac Blaas, Ravi Chand Bollineni, Marina Delic-Sarac, Trung T. Tran, Cathrine Knetter, Ke-Zheng Dai, Torfinn Støve Madssen, John T. Vaage, Alice Gustavsen, Weiwen Yang, Lise Sofie Haug Nissen-Meyer, Karolos Douvlataniotis, Maarja Laos, Morten Milek Nielsen, Bernd Thiede, Arne Søraas, Fridtjof Lund-Johansen, Even H. Rustad, Johanna Olweus
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.celrep.2023.111995    
[Article Type] Article
[Source] PMC

Meyer et al. identify peptide sequences from SARS-CoV-2 that are commonly recognized by CD8 T cells in convalescents. They demonstrate that these sequences are conserved in VOC. Thus, the emergence of VOC is not driven by escape from T cell immunity.

All Keywords
【저자키워드】 SARS-CoV-2, immunoprevalence, epitope, immunodominance, CD8 T cell,