Liu et al. isolate two nanobodies (R14 and S43) and construct their multivalent derivatives with increased potencies and breadth against SARS-CoV-2 variants. Particularly, decameric R14, maintaining similar activities after aerosolization, efficiently prevents BA.2 infections in both pre- and post-exposure prophylactic settings in vivo and deserves further development.
All Keywords
【저자키워드】 SARS-CoV-2, omicron, nanobody, sarbecovirus, cross-reactive antibody, IgM antibody, inhalable administration,
【저자키워드】 SARS-CoV-2, omicron, nanobody, sarbecovirus, cross-reactive antibody, IgM antibody, inhalable administration,