Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents

Published on
Journal: Molecular Therapy. Nucleic Acids
[저자] Amy D. Gelinas, Tiong Kit Tan, Sai Liu, Javier G. Jaramillo, James Chadwick, Adam C. Harding, Chi Zhang, Brian E. Ream, Chelsea N. Chase, Matthew R. Otis, Thomas Lee, Daniel J. Schneider, William S. James, Nebojsa Janjic
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.omtn.2023.01.008    
[Article Type] Original Article
[Source] PMC

We report a generally applicable method for developing modified DNA aptamer antagonists to viral targets, in this case, the SARS-CoV-2 spike protein. We identified an antiviral agent with potent activity against all variants of concern of SARS-CoV-2. Broad neutralization activity is due to occupancy of a conserved epitope overlapping the receptor-binding motif.

All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, variants of concern, aptamer, viral neutralization, SELEX, MT: Oligonucleotides, Therapies and Applications, modified DNA,