Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered.
All Keywords
【저자키워드】 immune response, Bisphosphonates, Glycoproteins, SARS Coronavirus, 【초록키워드】 COVID-19 disease, T cell, inhibitor, severe COVID-19 disease, boost, lysosome, SARS-CoV-2 virions, GTPase, acute response, Prevent, immunostimulant, activate, endosomal pathway, lung;, 【제목키워드】 SARS-COV-2 infection, dendritic cell, immunostimulant,
【저자키워드】 immune response, Bisphosphonates, Glycoproteins, SARS Coronavirus, 【초록키워드】 COVID-19 disease, T cell, inhibitor, severe COVID-19 disease, boost, lysosome, SARS-CoV-2 virions, GTPase, acute response, Prevent, immunostimulant, activate, endosomal pathway, lung;, 【제목키워드】 SARS-COV-2 infection, dendritic cell, immunostimulant,