Graphical abstract Mechanisms of nucleolin-mediated SARS-CoV-2 infection : 1. SARS-CoV-2 induces nucleolar to cytoplasmic translocation of nucleolin; In the cytoplasm, nucleolin interacts with the viral nucleoprotein and host G3BP1 in stress granules and increases viral proliferation via a direct increase in translation of replication proteins such as G3BP1 (2), nucleoprotein and RdRp (3); Nucleolin mediates viral-induction of apoptosis (4) and cell cycle arrest (5) via stimulation of p53 and Rb. Mechanisms of nucleolin-mediated SARS-CoV-2 infection: 1. SARS-CoV-2 induces nucleolar to cytoplasmic translocation of nucleolin; In the cytoplasm, nucleolin interacts with the viral nucleoprotein and host G3BP1 in stress granules and increases viral proliferation via a direct increase in translation of replication proteins such as G3BP1 (2), nucleoprotein and RdRp (3); Nucleolin mediates viral-induction of apoptosis (4) and cell cycle arrest (5) via stimulation of p53 and Rb. Image 1
【저자키워드】 SARS-CoV-2, COVID, aptamer, nucleoprotein, Nucleolin,