The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related comorbidities are strictly related with worse clinical outcomes of COVID-19 disease. Recently, there is a growing interest in the clinical use of ketogenic diets (KDs), particularly in the context of severe obesity with related metabolic complications. KDs have been proven effective for a rapid reduction of fat mass, preserving lean mass and providing an adequate nutritional status. In particular, the physiological increase in plasma levels of ketone bodies exerts important anti-inflammatory and immunomodulating effects, which may reveal as precious tools to prevent infection and potential adverse outcomes of COVID-19 disease. We discuss here the importance of KDs for a rapid reduction of several critical risk factors for COVID-19, such as obesity, type 2 diabetes and hypertension, based on the known effects of ketone bodies on inflammation, immunity, metabolic profile and cardiovascular function. We do believe that a rapid reduction of all modifiable risk factors, especially obesity with its metabolic complications, should be a pillar of public health policies and interventions, in view of future waves of SARS-CoV-2 infection.
【저자키워드】 SARS-CoV-2, Inflammation, obesity, diabetes, hyperglycaemia, VLCKD, Metabolic rehabilitation, 【초록키워드】 COVID-19, public health, Risk factors, Immunity, Anti-inflammatory, SARS-COV-2 infection, Infection, Comorbidity, novel coronavirus disease, risk factor, hypertension, COVID-19 disease, Clinical outcome, adverse outcome, Cardiovascular function, complications, plasma, Critical, nutritional status, physiological, reduction, health-care system, Fat mass, Clinical use, lean mass, health condition, immunomodulating, Effect, Effects, Prevent, effective, increase in, ketogenic, type 2 diabete, 【제목키워드】 Glucose, ketogenic,