With the emergence of new SARS-CoV-2 variants, there is a need for pan-variant Spike binders to inhibit viral entry. Using a novel pipeline combining cryo-EM and Rosetta, Remesh et al. characterize the mechanism of high-affinity interactions of designed ACE2 mimetic binders and show that they neutralize the Omicron variant.
All Keywords
【저자키워드】 spike, cryo-EM, SARS-CoV-2 Omicron variant, Rosetta, Pseudovirus neutralization, Protein therapeutics, ACE2 receptor traps,
【저자키워드】 spike, cryo-EM, SARS-CoV-2 Omicron variant, Rosetta, Pseudovirus neutralization, Protein therapeutics, ACE2 receptor traps,