In SARS-CoV-2-infected patients, obesity, hypertension, and diabetes are dangerous factors that may result in death. Priority in detection and specific therapies for these patients are necessary. We wanted to investigate the impact of obesity and metabolic syndrome (MS) on the clinical course of COVID-19 and whether prognostic biomarkers described are useful to predict the evolution of COVID-19 in patients with obesity or MS. This prospective cohort study included 303 patients hospitalized for COVID-19. Participants were first classified according to the presence of obesity; then, they were classified according to the presence of MS. Clinical, radiologic, and analytical parameters were collected. We reported that patients with obesity presented moderate COVID-19 symptoms and pneumonia, bilateral pulmonary infiltrates, and needed tocilizumab more frequently. Meanwhile, patients with MS presented severe pneumonia and respiratory failure more frequently, they have a higher mortality rate, and they also showed higher creatinine and troponin levels. The main findings of this study are that IL-6 is a potential predictor of COVID-19 severity in patients with obesity, while troponin and LDH can be used as predictive biomarkers of COVID-19 severity in MS patients. Therefore, treatment for COVID-19 in patients with obesity or MS should probably be intensified and personalized.
【저자키워드】 COVID-19, SARS-CoV-2, Pneumonia, obesity, prediction, metabolic syndrome, personalized therapy, 【초록키워드】 Evolution, therapy, Biomarker, Respiratory failure, Tocilizumab, IL-6, COVID-19 severity, LDH, Symptom, prospective cohort study, hypertension, Moderate COVID-19, Clinical course, clinical, Patient, death, mortality rate, severe pneumonia, patients, predict, prognostic biomarker, creatinine, Predictive, Factor, bilateral pulmonary infiltrates, syndrome, priority, troponin levels, participant, SARS-CoV-2-infected patients, parameter, described, radiologic, collected, reported, can be used, diabete, COVID-19 in patient, patients hospitalized, patients with obesity, treatment for COVID-19, 【제목키워드】 metabolic,