SARS-CoV-2 RBD vaccines are cost effective but require methods to increase their potency. Dickey et al. use a computational design method to create a stabilized non-glycosylated RBD that can be fused to a nanoparticle carrier, boosting its potency to levels of a gold-standard spike antigen.
All Keywords
【저자키워드】 glycosylation, immunogen, nanoparticle, structure-based design, structural vaccinology, SPEEDesign, stabilized,
【저자키워드】 glycosylation, immunogen, nanoparticle, structure-based design, structural vaccinology, SPEEDesign, stabilized,