We aimed to investigate whether statin therapy is associated with the incidence of coronavirus disease 2019 (COVID-19) among the South Korean population. In addition, we examined whether statin therapy affects hospital mortality among COVID-19 patients. The National Health Insurance Service (NHIS)-COVID-19 database in South Korea was used for data extraction for this population-based cohort study. A total of 122,040 adult individuals, with 22,633 (18.5%) in the statin therapy group and 101,697 (91.5%) in the control group, were included in the analysis. Among them, 7780 (6.4%) individuals were diagnosed with COVID-19 and hospital mortality occurred in 251 (3.2%) COVID-19 cases. After propensity score matching, logistic regression analysis showed that the odds of developing COVID-19 were 35% lower in the statin therapy group than in the control group (odds ratio: 0.65, 95% confidence interval: 0.60 to 0.71; p < 0.001). Regarding hospital mortality among COVID-19 patients, the multivariable model indicated that there were no differences between the statin therapy and control groups (odds ratio: 0.74, 95% confidence interval: 0.52 to 1.05; p = 0.094). Statin therapy may have potential benefits for the prevention of COVID-19 in South Korea. However, we found that statin therapy does not affect the hospital mortality of patients who are diagnosed with COVID-19.
【저자키워드】 Hospital mortality, infections, Hydroxymethylglutaryl-CoA Reductase Inhibitors, 【초록키워드】 COVID-19, coronavirus disease, therapy, Mortality, hospital, database, Patient, statin, incidence, South Korea, COVID-19 patients, Korean, population-based cohort, Analysis, propensity score matching, COVID-19 cases, insurance, Logistic regression analysis, control group, individual, no difference, data extraction, South, multivariable model, service, Affect, prevention of COVID-19, was used, occurred, examined, indicated, addition, potential benefit, not affect, individuals, diagnosed with COVID-19, 【제목키워드】 statin, South Korea, insurance, service,