Anguera, Vaughan, and colleagues show that lung alveolar type 2 (AT2s) cells maintain X chromosome inactivation with fewer epigenetic modifications on the inactive X, with very high numbers of X-linked genes that “escape” transcriptional silencing. AT2 cells also exhibit significant genome-wide sex-biased gene expression, which likely influences lung physiology and pathophysiologic responses.
All Keywords
【저자키워드】 ACE2, sex differences, alveolar type 2 cells, X chromosome inactivation, sex-biased gene expression, heterochromatic modifications, lung progenitors, XCI escape genes, Xist RNA,
【저자키워드】 ACE2, sex differences, alveolar type 2 cells, X chromosome inactivation, sex-biased gene expression, heterochromatic modifications, lung progenitors, XCI escape genes, Xist RNA,