(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6–10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
【저자키워드】 COVID-19, Inflammation, Cytokine storm, heart failure, transthoracic echocardio-graphy, left ventricular systolic dysfunction, diastolic dysfunction, 【초록키워드】 Hospitalized, Pneumonia, computer tomography, hospital, Infection, database, Symptoms, discharge, inflammatory factors, body mass index, COVID-19 infection, outbreak, persistence, morbidity, Patient, complications, age, BMI, disease, moderate, multivariate regression analysis, patients, predict, marker, Evidence, COVID-19 patient, In-hospital, dysfunction, Thorax, myocardial necrosis, CK-MB, acute phase, alteration, laboratory data, decrease, diastolic, initial, responsible, subsequent, correlated, evidenced, statistically, TTE, ventricular, 【제목키워드】 cardiovascular, function, alteration, left,