Both lung adenocarcinoma and coronavirus disease 2019 would cause pulmonary inflammation. Angiotensin-converting enzyme 2, the functional receptor of SARS-CoV-2, also plays a key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and microRNA profiles were obtained from The Cancer Genome Atlas and Gene Expression Omnibus followed by bioinformatics analysis. A network which regards angiotensin-converting enzyme 2 as the center was structured. In addition, via immunological analysis to explore the essential mechanism of SARS-CoV-2 susceptibility in lung adenocarcinoma. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 correlated differently expressed mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 correlated differently expressed microRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened. Interestingly, the most frequent toll-like receptor signaling pathway was enriched by mRNA (interlukin 6) and miRNA (miR-125b-5p) sets simultaneously. In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, IL6, lung adenocarcinoma, miR-125b-5p, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, SARS-COV-2 infection, microRNA, miRNA, risk, angiotensin-converting enzyme 2, Toll-like receptor, pulmonary inflammation, mRNA, lung adenocarcinoma, CXCL9, network, signaling pathway, receptor, Bioinformatics analysis, MicroRNAs, patients, mechanism, Angiotensin-converting enzyme, Analysis, angiotensin, mRNAs, followed by, tissue, profile, enzyme, SARS-CoV-2 susceptibility, center, IRAK3, Gene Expression Omnibus, MMP12, AZU1, FCN3, HYAL1, Alter, immunological, addition, screened, functional, expressed, correlated, Atla, assumed, was increased, 【제목키워드】 Patient, higher risk,