We have reviewed current data on the anti-inflammatory effects of amantadine and memantine in clinical and in vivo models of inflammation, and we propose that these effects have potential interest for the treatment of the SARS-CoV-2 infection (COVID-19 disease). To that end, we performed a literature search using the PubMed Database from 1966 up to October 31 2020, crossing the terms “amantadine” and “memantine” with “inflammation” and “anti-inflammatory”. Amantadine and/or memantine have shown anti-inflammatory effects in chronic hepatitis C, in neuroinflammation induced by sepsis and by lipopolysaccharides, experimental models of multiple sclerosis, spinal cord injury, and respiratory diseases. Since the inflammatory response is one of the main pathogenetic mechanisms in the progression of the SARS-CoV-2 infection, anti-inflammatory effects of amantadine and memantine could be hypothetically useful in the treatment of this condition. This potential utility deserves further research.
【저자키워드】 COVID-19, SARS-CoV-2, Anti-inflammatory effects, therapy, amantadine, Memantine, 【초록키워드】 Treatment, Inflammation, multiple sclerosis, Infection, Sepsis, progression, respiratory diseases, COVID-19 disease, Hepatitis, Research, Neuroinflammation, utility, mechanism, experimental model, Inflammatory response, Spinal cord injury, anti-inflammatory effect, Effect, shown, performed, in vivo model, the SARS-CoV-2, 【제목키워드】 Therapeutics, Effect,