The number of COVID-19 patients is still growing exponentially worldwide due to the high transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation are antiviral drugs, vaccines, and other adjuvants that could relieve symptoms or improve the healing process. In this review, twelve therapeutic agents that could play a role in prophylaxis or improvement of the COVID-19-associated symptoms (as add-on substances) are discussed. Agents were identified based on their known pharmacologic mechanism of action in viral and/or nonviral fields and are postulated to interact with one or more of the seven known mechanisms associated with the SARS-CoV-2 virus: (i) regulation of the immune system; (ii) virus entrance in the cell; (iii) virus replication; (iv) hyperinflammation; (v) oxidative stress; (vi) thrombosis; and (vii) endotheliitis. Selected agents were immune transfer factor (oligo- and polypeptides from porcine spleen, ultrafiltered at <10 kDa; Imuno TF ® ), anti-inflammatory natural blend ( Uncaria tomentosa , Endopleura uchi and Haematoccocus pluvialis; Miodesin ® ), zinc, selenium, ascorbic acid, cholecalciferol, ferulic acid, spirulina, N-acetylcysteine, glucosamine sulfate potassium hydrochloride, trans-resveratrol, and maltodextrin-stabilized orthosilicic acid (SiliciuMax ® ). This review gives the scientific background on the hypothesis that these therapeutic agents can act in synergy in the prevention and improvement of COVID-19-associated symptoms.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Therapeutics, dietary supplement, drug, Pharmacology, adjuvant, immunological, compounding, 【초록키워드】 Anti-inflammatory, Vaccines, antiviral drugs, Symptom, virus, Symptoms, immune, Endotheliitis, Prophylaxis, Transmissibility, therapeutic agent, Potassium, synergy, mechanism of action, mechanism, spleen, Hypothesis, COVID-19 patient, ferulic acid, agent, Regulation, polypeptide, trans-resveratrol, Seven, oxidative, IMPROVE, in viral, immune transfer, the SARS-CoV-2, the SARS-CoV-2 virus, Uncaria, 【제목키워드】 Strategy,