Pyoderma gangrenosum (PG) is a rare and chronic neutrophil inflammation belonging to the spectrum of autoinflammatory disorders. Immunosuppressive therapy is the cornerstone of successful treatment. However, due to the global COVID-19 pandemic, physicians struggle with therapeutic strategies during infection. This paper describes the case of a 58-year-old patient with a very painful, rapidly increasing wound on his right foot, which was diagnosed as pyoderma gangrenosum. Five weeks after the initial treatment with high-dose immunosuppressives (combination therapy with cyclosporine A and systemic methylprednisolone), he became infected with COVID-19. Reduction in the immunosuppressive dosage proved effective, as the patient recovered from COVID-19 without any complication and showed rapid wound healing.
【저자키워드】 COVID-19, Corticosteroids, Immunosuppression, autoinflammatory disease, cyclosporine, Pyoderma gangrenosum, 【초록키워드】 Methylprednisolone, Treatment, Inflammation, COVID-19 pandemic, neutrophil, Infection, combination therapy, Patient, therapeutic strategy, immunosuppressive therapy, immunosuppressive, High-dose, disorders, dosage, wound healing, physician, effective, initial, the patient, diagnosed, infected with COVID-19, pyoderma, 【제목키워드】 Contracting,