During the critical early stages of an emerging pandemic, limited availability of pathogen-specific testing can severely inhibit individualized risk screening and pandemic tracking. Standard clinical laboratory tests offer a widely available complementary data source for first-line risk screening and pandemic surveillance. Here, we propose an integrated framework for developing clinical-laboratory indicators for novel pandemics that combines population-level and individual-level analyses. We apply this framework to 7,520,834 clinical laboratory tests recorded over five years and find clinical-lab-test combinations that are strongly associated with SARS-CoV-2 PCR test results and Multisystem Inflammatory Syndrome in Children (MIS-C) diagnoses: Interleukin-related tests (e.g. IL4, IL10) were most strongly associated with SARS-CoV-2 infection and MIS-C, while other more widely available tests (ferritin, D-dimer, fibrinogen, alanine transaminase, and C-reactive protein) also had strong associations. When novel pandemics emerge, this framework can be used to identify specific combinations of clinical laboratory tests for public health tracking and first-line individualized risk screening.
【저자키워드】 Translational research, viral infection, Epidemiology, 【초록키워드】 public health, pandemic, SARS-COV-2 infection, C-reactive protein, risk, D-dimer, ferritin, MIS-C, Surveillance, Pandemics, fibrinogen, Critical, early stage, Combination, Standard, complementary, Laboratory test, Alanine, SARS-CoV-2 PCR test, IL10, offer, FIVE, identify, inhibit, can be used, analyses, recorded, associations, pathogen-specific, IL4, 【제목키워드】 COVID-19, MIS-C,