Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, lung cancer, TMPRSS2, 【초록키워드】 Gene Expression, Prognosis, SARS-COV-2 infection, Cancer, lung, Patient, tissue expression, lung adenocarcinoma, age, patients, COVID-19 patient, cancer patient, higher risk, enzyme, transmembrane serine protease, protein levels, recent, susceptible, Cell, event, reported, investigated, 【제목키워드】 SARS-COV-2 infection, susceptibility, lung cancer patient,
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, lung cancer, TMPRSS2, 【초록키워드】 Gene Expression, Prognosis, SARS-COV-2 infection, Cancer, lung, Patient, tissue expression, lung adenocarcinoma, age, patients, COVID-19 patient, cancer patient, higher risk, enzyme, transmembrane serine protease, protein levels, recent, susceptible, Cell, event, reported, investigated, 【제목키워드】 SARS-COV-2 infection, susceptibility, lung cancer patient,