The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
All Keywords
【초록키워드】 SARS-CoV-2, viral infection, Neutralizing antibodies, interferon, innate immune system, therapeutic, Adaptive immune response, Pathways, Cytotoxic T cell, Activation, Implications, block, effective, include, activate, reduce, 【제목키워드】 SARS-CoV-2, interferon, blockade,
【초록키워드】 SARS-CoV-2, viral infection, Neutralizing antibodies, interferon, innate immune system, therapeutic, Adaptive immune response, Pathways, Cytotoxic T cell, Activation, Implications, block, effective, include, activate, reduce, 【제목키워드】 SARS-CoV-2, interferon, blockade,