ABSTRACT Severe coronavirus disease 2019 can be associated with progressive respiratory failure. In addition to respiratory support and other supportive care, use of corticosteroids has shown to improve outcome. Despite the use of steroids, a significant proportion of patients progressively worsen. Adjunct immunomodulators have been studied in addition to steroids in these patients. Here we present a successful use of tofacitinib, a Janus Kinase inhibitor, in conjunction with dexamethasone for a patient with rapid worsening of respiratory status and with high level of serum inflammatory biomarkers.
All Keywords
【저자키워드】 COVID-19,dexamethasone , immunomodulation , 【초록키워드】 Dexamethasone, coronavirus disease, outcome, immunomodulator, Patient, patients, Kinase inhibitor, Tofacitinib, supportive care, Respiratory Support, steroid, janus, worsening, adjunct, progressive respiratory failure, Serum inflammatory biomarkers, IMPROVE, shown, proportion, addition, use of corticosteroid, use of steroids, 【제목키워드】 report, adjunct,
【저자키워드】 COVID-19,