Background To date, there is no comprehensive systematic review and meta-analysis to assess the suitability of COVID-19 vaccines for mass immunization. The current systematic review and meta-analysis was conducted to evaluate the safety and immunogenicity of novel COVID-19 vaccine candidates under clinical trial evaluation and present a contemporary update on the development and implementation of a potential vaccines. Methods For this study PubMed, MEDLINE, and Embase electronic databases were used to search for eligible studies on the interface between novel coronavirus and vaccine design until December 31, 2020. Results We have included fourteen non-randomized and randomized controlled phase I-III trials. Implementation of a universal vaccination program with proven safety and efficacy through robust clinical evaluation is the long-term goal for preventing COVID-19. The immunization program must be cost-effective for mass production and accessibility. Despite pioneering techniques for the fast-track development of the vaccine in the current global emergency, mass production and availability of an effective COVID-19 vaccine could take some more time. Conclusion Our findings suggest a revisiting of the reported solicited and unsolicited systemic adverse events for COVID-19 candidate vaccines. Hence, it is alarming to judiciously expose thousands of participants to COVID-19 candidate vaccines at Phase-3 trials that have adverse events and insufficient evidence on safety and effectiveness that necessitates further justification.
【저자키워드】 COVID-19, immunogenicity, Candidate vaccines, Solicited and Unsolicited Systemic Adverse Events, 【초록키워드】 Meta-analysis, Efficacy, COVID-19 vaccine, vaccination, clinical trial, Trial, Vaccines, Vaccine design, systematic review, database, immunization, Novel coronavirus, Randomized, clinical evaluation, implementation, adverse event, Effectiveness, trials, Evidence, candidate, participant, candidate vaccine, effective, robust, Result, evaluate, reported, conducted, were used, non-randomized, the vaccine, eligible, systemic adverse event, 【제목키워드】 coronavirus disease, Meta-analysis, Vaccine, clinical trial, systematic review, implementation, development,