We hypothesized that the spread of SARS-CoV-2 in urine during a severe COVID-19 infection may be the expression of the worsening disease evolution. Therefore, the aim of this study was to verify if the COVID-19 disease severity is related to the viral presence in urine samples. We evaluated the clinical evolution in acute COVID-19 patients admitted in the sub-intensive care and intensive care units between 28 of December 2020 and 15th of February 2021 and being positive for SARS-CoV-2 RNA in the respiratory tract, including repeated endotracheal aspirates (ETA), sputum, nasopharyngeal swabs (NPS) and urine. We found that those subjects with SARS-COV-2 in the urine at admittance (8 out of 60 eligible patients) had a more severe disease than those with negative SARS-CoV-2 in urine. Further, they showed an increase in fibrinogen and (C-reactive Protein) CRP serum levels, requiring mechanic ventilation. Of those with positive SARS-CoV-2 in the urine, 50% died. According to our preliminary results, it seems that the presence of SARS-CoV-2 in the urine characterizes patients with a more severe disease and is also related to a higher death rate.
【저자키워드】 COVID-19, SARS-CoV-2, unusual COVID, atypical COVID-19, SARS-CoV-2 urine, 【초록키워드】 Evolution, Ventilation, intensive care unit, CRP, sputum, Spread, Nasopharyngeal swab, Patient, Urine, fibrinogen, SARS-CoV-2 RNA, respiratory tract, disease, expression, Care, severe disease, death rate, Severe COVID-19 Infection, Eligible patients, subject, serum levels, worsening, COVID-19 disease severity, viral presence, acute COVID-19, clinical evolution, positive, NPs, repeated, died, evaluated, increase in,