The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group). In 180 days, the observation we noted comparable mortality rate in AT and no AT groups (38.5% vs. 41.1%, p = 0.51). Similarly, we did not observe any statistically significant differences in admission in the intensive care unit (14.1% vs. 9.6%, p = 0.20), intubation and mechanical ventilation (15.0% vs. 11.6%, p = 0.38), catecholamines usage (14.3% vs. 13.8%, p = 0.86), and bleeding rate (6.3% vs. 8.9%, p = 0.37) in both groups. Our results suggest that antithrombotic treatment prior to COVID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, anticoagulation, morbidity, thromboembolic complications, 6 months outcome, 【초록키워드】 Treatment, coronavirus disease, intensive care, mechanical ventilation, SARS-COV-2 infection, intubation, Laboratory, COVID-19 infection, humans, Patient, bleeding, Retrospective analysis, morbidity and mortality, mortality rate, incidence, group, Admission, PSM, Protective, Antithrombotic, propensity score matching, medical record, observation, Anticoagulant treatment, statistically significant difference, Thromboembolic event, observé, evaluate, unlikely, receiving, comparable, in both groups, patients hospitalized, with COVID-19, 【제목키워드】 Impact, Month,