COVID-19 has been shown to present with varied clinical course, necessitating a need for more specific diagnostic tools that could identify severe cases and predict outcomes during COVID-19 infection. Recent evidence has shown an expanded potential role for calprotectin, both as a diagnostic tool and also as a tool in stratifying COVID-19 patients in terms of severity. Therefore, this systematic review and meta-analysis aims to evaluate the levels of calprotectin in severe and non-severe COVID-19 and also identify the implication of raised calprotectin levels. MEDLINE, EMBASE, The Cochrane Library, Web of science and MedRxiv were searched. Meta-analysis was done to compare the serum/fecal levels of calprotectin between severe and non-severe COVID-19 infections. A total of ten studies included in the review (eight had quantitative data while two were qualitative). A pooled analysis of the eight studies from 613 patients who were RT-PCR positive for COVID-19 (average age = 55 years; 52% males) showed an overall estimate as 1.34 (95%CI: 0.77, 1.91). In conclusion, calprotectin levels have been demonstrated to be significantly elevated in COVID-19 patients who develop the severe form of the disease, and it also has prognostic importance.
【저자키워드】 COVID-19, Meta-analysis, Biomarker, systematic review, calprotectin, 【초록키워드】 severity, diagnostic, outcome, RT-PCR, Clinical course, COVID-19 infection, Patient, age, prognostic, predict, Evidence, Analysis, COVID-19 patient, COVID-19 infections, average, Cochrane Library, medRxiv, Severe case, Quantitative data, positive, recent, males, shown, identify, develop, evaluate, significantly, the disease, raised, elevated, eight, searched, demonstrated, Web, was done, 【제목키워드】 review, interest,