Since first being identified in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an etiological agent behind Coronavirus disease 19 (COVID-19), has caused three waves of a global pandemic, with a fourth in progress. Despite its high percentage of asymptomatic and low-symptomatic courses of illness, the SARS-CoV-2 pandemic has claimed a higher death toll than the SARS-CoV and MERS-CoV epidemics because of its high infectivity when compared to the other coronaviruses. High COVID-19 mortality is associated with age and other coexisting morbidities, as well as healthcare quality. According to several studies, pregnant women are at a higher risk of severe COVID-19 infection and adverse pregnancy outcomes (caesarean delivery, pre-term birth, low birth weight, preeclampsia, ICU admission, and need for mechanical ventilation). In our review of recent literature, we focused on the effects of COVID-19 in pregnant women, emphasizing the subcellular pathophysiology of SARS-CoV-2. In this paper, we concentrate on the pathophysiology of sub-cellular changes in COVID-19 and endeavor to highlight the aspects that manifest in physiological pregnancy and potentially create a higher risk of SARS-CoV-2 infection and acute COVID-19 symptoms. Understanding how pregnancy-associated changes can cause a synergistic effect with COVID-19 may point us in the right direction for future prophylaxis and treatment for women undergoing COVID-19 during pregnancy.
【저자키워드】 COVID-19, Vaccine, SAR-CoV-2, Pregnancy, 【초록키워드】 Treatment, SARS-CoV-2, coronavirus, pandemic, mechanical ventilation, SARS-CoV, SARS-COV-2 infection, Epidemics, outcome, MERS-CoV, Symptoms, Prophylaxis, global pandemic, pregnant women, Asymptomatic, pathophysiology, healthcare, ICU admission, death, understanding, age, women, coronavirus disease 19, change, COVID-19 mortality, physiological, Severe COVID-19 Infection, acute respiratory syndrome, higher risk, other coronaviruses, morbidities, etiological agent, acute COVID-19, Effect, synergistic, highlight, Course, caused, changes in, subcellular, claimed, the SARS-CoV-2, with COVID-19, 【제목키워드】 Factor,