The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
【저자키워드】 SARS-CoV-2, pandemic, ferritin, Liver injury, AST/ALT ratio, 【초록키워드】 hospital, diagnostic, LDH, outcome, Spread, serum, Epidemic, outbreak, Patient, Spain, AST, Mild, characteristic, disease, Admission, patients, COVID-19 patients, marker, ALT, Healthcare system, phosphatase, positive correlation, novel coronavirus SARS-CoV-2, SARS-CoV-2 virus infection, gamma-glutamyltransferase, upper, AST/ALT, electronic medical record, normal, significant changes in, analyzed, evaluated, elevated, upregulated, ALP, ULN, 【제목키워드】 Test, Spain, function,